Catalog No.
Product Name
Application
Product Information
Citations
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CYP3A Inhibitor
ALT-2074 is a CYP3A inhibitor with an IC50 value ranging from 2.0 to 2.6 μM, functioning as a catalytic analogue of glutathione peroxidase. Although it demonstrates a weak inhibitory effect on CYP3A in vivo, it serves as a valuable tool for studying the role of oxidative stress in inflammatory diseases, including acute coronary syndrome. This compound is particularly useful in research investigating the interplay between reactive oxygen species and metabolic pathways. -
ALDH1A Inhibitor
ALDH1A Inhibitor 673A is a selective inhibitor targeting ALDH1A1, ALDH1A2, and ALDH1A3, with IC50 values of 246 nM, 230 nM, and 348 nM, respectively. This compound demonstrates minimal inhibitory effects on other ALDH family members. It has been shown to induce necroptotic death in ovarian cancer stem-like cells and cause DNA double strand breaks in cancer cells. ALDH1A Inhibitor 673A serves as a valuable tool for researching ovarian cancer mechanisms and treatment strategies. -
Necroptosis/11β-HSD1 Inhibitor
Necroptosis-IN-3 is a selective inhibitor of necroptosis, primarily targeting TNF-α induced necroptotic pathways. Additionally, this compound inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby modulating glucocorticoid metabolism. Its key biological activities make it a valuable tool for researchers studying necroptosis and related cellular mechanisms in various disease models. -
Herbicide/Microtubule inhibitor
Ethalfluralin is a dinitroaniline herbicide that functions as a microtubule inhibitor. By disrupting intranuclear spindle formation, Ethalfluralin effectively obstructs nuclear division and cytokinesis in parasites. This compound also enhances phosphorylation of NF-κB and P38 MAPK while inhibiting the PI3K/AKT signaling pathway, leading to impaired mitochondrial functionality, apoptosis, endoplasmic reticulum stress, autophagy, and increased reactive oxygen species (ROS) production. Ethalfluralin is particularly relevant for research applications in toxoplasmosis and related parasitic diseases. -
Herbicide
Antimalarial agent 17 is a potent photosystem II inhibitor with dual functionality as both an antimalarial agent and a herbicide. This compound demonstrates effective post-emergence herbicidal activity, comparable to that of leading commercial herbicides. It can be utilized in agricultural research to study herbicide resistance mechanisms and in the development of novel herbicidal agents. -
Fungal Metabolite
Asterriquinol D dimethyl ether is a fungal metabolite that acts as an inhibitor of cell proliferation in mouse myeloma NS-1 cell lines, exhibiting an IC50 of 28 µg/mL. Additionally, it demonstrates inhibitory effects on Tritrichomonas foetus. This compound is valuable for research applications in studying fungal metabolism and evaluating potential therapeutic agents against specific cell types and pathogens. -
DGAT-1 Inhibitor
Aphadilactone C is a selective inhibitor of diacylglycerol O-acyltransferase 1 (DGAT-1), exhibiting an IC50 of 0.46 μM. In addition to its DGAT-1 inhibition, Aphadilactone C demonstrates notable antimalarial properties with an IC50 value of 170 nM. This compound is valuable for research related to lipid metabolism and malaria treatment studies. -
PDEB1 Inhibitor
PDEB1-IN-1 is a selective inhibitor of Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1), exhibiting an IC50 value of 0.95 μM. This compound effectively inhibits the proliferation of T. brucei, with an EC50 of 26 μM, making it a valuable tool for research in trypanosomiasis. PDEB1-IN-1 can be utilized in studies aimed at understanding the role of PDEB1 in the pathogenesis of the disease and for exploring therapeutic avenues in antiparasitic drug development. -
CYP51 Inhibitor
VNI is a potent inhibitor of cytochrome P450 51 (CYP51), targeting sterol synthesis in the parasite Trypanosoma cruzi. Its mechanism of action disrupts the biosynthesis of essential sterols, leading to impaired growth and viability of the pathogen. VNI is primarily utilized in research focused on anti-parasitic strategies and the development of therapeutics for Chagas disease. -
CYP51 Inhibitor
CYP51-IN-15 is a selective inhibitor of CYP51, targeting the enzyme in Naegleria fowleri. With an EC50 value of 1.5 μM, it demonstrates potent biological activity against this pathogenic organism. This compound is valuable in research aimed at elucidating mechanisms of action and developing therapeutic strategies against Naegleria fowleri infections. -
Insect Pheromone
(Z)-7-Hexadecenal is an insect pheromone that plays a crucial role in the attraction of male insects. This compound has been isolated from female Heliothis virescens moths and is pivotal for understanding insect communication and behavior. It is commonly employed in research applications related to pest control strategies and the study of insect olfactory systems. -
CYP51 Inhibitor
LP8 is a pyridinyl-type inhibitor of cytochrome P450 51 (CYP51), specifically targeting the sterol biosynthesis pathway in various pathogens. This compound exhibits significant biological activity against Trypanosoma cruzi, the causative agent of Chagas disease and American trypanosomiasis. LP8 is valuable for research applications aimed at elucidating the mechanisms of these diseases and developing potential therapeutic strategies. -
Dinitroaniline Herbicide
Nitralin is a dinitroaniline herbicide that functions by disrupting microtubule polymerization, thereby inhibiting cell division in target organisms. This compound demonstrates significant inhibitory activity against Cryptosporidium parvum, with an IC50 of 4.5 µM. Nitralin is primarily utilized in research focused on herbicidal action mechanisms and the control of protozoal infections. -
Fungal Metabolite
Lachnumon is a fungal metabolite known for its nematicidal and antimicrobial properties. This compound exhibits significant biological activity against nematodes and various microbial strains, making it a valuable tool for research in agricultural and pharmaceutical applications. Its unique mechanism of action offers potential insights into pest management and the development of antimicrobial agents. -
Pv NMT Inhibitor
NMT-IN-3 is a selective inhibitor of N-myristoyltransferase (NMT) targeting Plasmodium vivax. With an IC50 of 38 mM, it demonstrates significant inhibitory activity against Pv NMT. This reagent is valuable for studying myristoylation processes in malaria research and evaluating potential therapeutic strategies against Plasmodium infections. -
Phenol
2-Methylcardol triene is a phenolic compound that exhibits potent α-glucosidase inhibition with an IC50 of 39.6 μM. Notably, this compound demonstrates schistosomicidal activity, effectively eliminating 100% of adult Schistosoma mansoni worms within 24 hours at concentrations of 100 and 200 μM. Additionally, 2-Methylcardol triene serves as a valuable precursor for synthesizing mono- and bis-benzoxazines, making it a versatile reagent for various chemical and biological research applications. -
DPPH Scavenger
Epicoccone B is a potent DPPH radical scavenger, exhibiting an IC50 value of 10.8 μM, indicating its effectiveness in neutralizing free radicals. This compound, isolated from C. globosum, also demonstrates significant α-glucosidase inhibition with an IC50 value of 27.3 μM. Additionally, Epicoccone B has been noted for its anti-HIV activity, making it a valuable reagent for oxidative stress studies and diabetes research. -
CYP3A Inhibitor
Cobicistat-d8 is a deuterated analog of Cobicistat, acting as a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC50 values ranging from 30 to 285 nM. This reagent functions primarily as a pharmacokinetic enhancer, improving the absorption and bioavailability of anti-HIV agents. Its role in modulating drug metabolism makes it a valuable tool in pharmaceutical research and drug development. -
α-Glucosidase/HMG-CoA reductase Dual Inhibitor
Ganomycin I is a dual inhibitor targeting α-Glucosidase and HMG-CoA reductase. It demonstrates significant anti-diabetic properties and inhibits HIV protease, contributing to its potential as an antiviral agent. Additionally, Ganomycin I shows effectiveness in preventing osteoclastogenesis, making it a valuable reagent for research in diabetes and bone metabolism. -
Herbicide
Altenuisol is a herbicidal compound derived from the pathogenic fungus of the genus Alternaria in Xanthium italicum. It demonstrates notable biological activity by promoting root growth in Pennisetum alopecuroides and Medicago sativa at low concentrations while inhibiting their growth at higher doses. Additionally, Altenuisol exhibits cytotoxic effects on HeLa cells and possesses antibacterial and antioxidant properties. This compound is anticipated to facilitate research in agricultural weed management, cancer biology, and antimicrobial studies. -
α-Glucosidase I Inhibitor
Celgosivir hydrochloride is an α-glucosidase I inhibitor that demonstrates significant antiviral activity by inhibiting bovine viral diarrhoea virus (BVDV) with an IC50 value of 1.27 μM in in vitro assays. This compound is valuable for researchers studying viral infections and exploring potential therapeutic strategies through glycosidase inhibition. Its ability to modulate glycosylation processes makes it a relevant tool for biochemical and pharmacological investigations. -
ER α-glucosidases I/II Inhihitor
IHVR-19029 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting an IC50 of 0.48 μM for α-glucosidase I. This compound demonstrates significant antiviral activity by effectively blocking the replication of various hemorrhagic fever viruses, including Dengue virus (DENV), Ebola virus (EBOV), and Rift Valley fever virus. Research applications include the exploration of antiviral strategies, especially in combination therapies, such as enhancing the efficacy of Favipiravir. -
Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
Glucosidase Inhibitor
Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies. -
Anti-oxidant, Lipid Peroxidation/5-lipoxygenase Inhibitor
LY221068 is a potent inhibitor of iron-dependent lipid peroxidation and 5-lipoxygenase, exhibiting notable antioxidant properties. This compound demonstrates significant anti-inflammatory activity, particularly in preclinical models of arthritis, such as the Freund's Complete Adjuvant-induced arthritis model in rats, where it effectively reduces bone damage and paw swelling. LY221068 serves as a valuable tool for investigating inflammatory processes and potential therapeutic approaches in arthritis research. -
MAO-A Inhibitor
Pirlindole mesylate is a selective and reversible inhibitor of monoamine oxidase A (MAO-A), playing a crucial role in the modulation of neurotransmitter metabolism. Additionally, Pirlindole exhibits antiviral activity against enterovirus D68 and coxsackievirus B3 (CV-B3), positioning it as a potential agent in virology research. This compound is valuable for studies focusing on depression, anxiety disorders, and the therapeutic mechanisms of neuronal regulation and viral infections. -
FXR Agonist
Vonafexor is a selective agonist of the farnesoid X receptor (FXR), offering an oral bioavailability profile. This compound has demonstrated substantial reductions in HBsAg levels when used in conjunction with Peg-IFNα. Vonafexor is primarily employed in anti-HBV research, making it a valuable reagent for studies focused on hepatitis B virus therapies. -
Herbicide
Cyprosulfamide is a herbicide that targets salinity stress in plants, enhancing their growth and resilience. It promotes vigorous development, including the formation of new tillers and early flowering, making it a valuable tool in agricultural research aimed at improving crop tolerance to unfavorable environmental conditions. This compound is useful for studies focused on plant physiology and stress response mechanisms. -
CYP1A1 Inhibitor
CYP1A1-IN-1 is a selective inhibitor of cytochrome P4501A1 (CYP1A1). This compound has demonstrated the ability to reduce bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii through the enhancement of macrophage phagocytosis. CYP1A1-IN-1 holds potential for advancing research in sepsis associated with multidrug-resistant (MDR) bacterial infections. -
Insect Pheromone
Caprazene is an insect pheromone precursor that plays a critical role in the development of semi-synthetic antibacterial antibiotics. This compound exhibits significant antimycobacterial activity, making it valuable for research on tuberculosis and Mycobacterium avium complex infections. Its ability to be isolated from the acid-treated caprazamycin (CPZ) A-G mixture enhances its utility in studying the mechanisms of bacterial resistance and developing effective therapeutic strategies. -
Gatifloxacin Derivative
3-Desmethyl Gatifloxacin is a derivative of Gatifloxacin that primarily targets bacterial DNA gyrase, inducing DNA cleavage. This compound is particularly useful in the study of gatifloxacin resistance, including in Quinolone-resistant mutants, making it a valuable tool for research on mechanisms of drug resistance in bacterial pathogens. -
Fungal Metabolite
Ophiobolin H is a fungal metabolite derived from Aspergillus ustus, demonstrating potent inhibitory activity against Bacillus subtilis. This compound also induces hyperacusia in day-old chicks at doses up to 375 mg/kg. Its unique biological properties make Ophiobolin H a valuable tool in research focusing on fungal metabolites and their effects on bacterial growth and sensory responses. -
Insect Pheromone
11-Octadecenal is a volatile aldehyde known for its role as an insect pheromone. Primarily associated with attracting male wax moths (Achroia grisella), this compound exhibits significant biological activity in communication and mating behaviors within certain insect species. It serves useful applications in entomological research and the development of synthetic sex pheromones for pest management. -
Antimicrobial Peptide
Cathepsin G(1-5) is an antimicrobial peptide derived from the clostripain-digested cathepsin G mixture. This peptide exhibits significant antimicrobial activity, making it valuable for research on host defense mechanisms and the development of novel therapeutic agents. Cathepsin G(1-5) is utilized in studies exploring its effects on bacterial pathogens and potential applications in infection control. -
DHFR Inhibitor
N-Didesmethyladitoprim is a metabolite of the selective bacterial dihydrofolate reductase (DHFR) inhibitor, Aditoprime. This compound effectively inhibits the conversion of dihydrofolic acid to tetrahydrofolic acid, demonstrating an IC50 of 47 nM against E. coli and 520 nM against L. casei DHFR. N-Didesmethyladitoprim exhibits broad-spectrum antibacterial activity and possesses favorable pharmacokinetic properties, making it a valuable tool for research in antimicrobial mechanisms and DHFR inhibition studies. -
DHFR Inhibitor
NSC309401 is a potent inhibitor of dihydrofolate reductase (DHFR) from E. coli, exhibiting an IC50 value of 189 nM and a KD of 14.57 nM. This compound is essential for studying folate metabolism and can be utilized in research applications related to antimicrobial drug development and cancer therapeutics. Its specificity for DHFR makes it a valuable tool for elucidating the biochemical pathways influenced by folate synthesis. -
DHFR Inhibitor
DHFR-IN-10 is a potent inhibitor of dihydrofolate reductase (DHFR), exhibiting an IC50 of 4.21 μM against M. tuberculosis DHFR. This compound demonstrates significant antituberculosis efficacy, making it a valuable tool in research focused on combating tuberculosis and studying DHFR-related pathways. Its effectiveness positions DHFR-IN-10 as a potential lead candidate for further development in anti-tubercular drug discovery. -
Herbicide
Bilanafos is an organic phosphine tripeptide antibiotic that exerts its effects by targeting and inhibiting protein synthesis in susceptible microorganisms. This herbicide demonstrates significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, as well as providing efficacy against various fungal plant pathogens. Bilanafos is utilized in agricultural research for developing effective strategies against microbial plant diseases. -
DHFR inhibitor
Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis. - Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor of the enzyme xanthine oxidase.
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Adenosine receptor antagonist
Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor capable of reversing ischemia-induced bradyasystole. -
Dehydrogenase inhibitor
Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. -
Protein kinase inhibitor
Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.
- Benserazid hydrochloride is an inhibitor of L-aromatic amino acid decarboxylase.
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Factor Xa inhibitor
BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
