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Biological Activity
SNX-5422 Mesylate (PF-04929113 Mesylate), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37?nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.19 mL | 80.95 mL | 161.91 mL |
| 0.5 mM | 3.24 mL | 16.19 mL | 32.38 mL |
| 1 mM | 1.62 mL | 8.1 mL | 16.19 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.24 mL |
*The above data is based on the productmolecular weight 617.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21512 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1173111-67-5 |
| Formula | C26H34F3N5O7S |
| M. Wt | 617.64 |
| Purity | >98% |
| Synonyms | PF-04929113 (Mesylate), PF04929113,PF-04929113 |
| SMILES | CS(=O)(O)=O.O=C1CC(C)(C)CC2=C1C(C(F)(F)F)=NN2C3=CC=C(C(N[[email protected]@H]4CC[[email protected]@H](OC(CN)=O)CC4)=C3)C(N)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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