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Biological Activity
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.51 mL | 82.57 mL | 165.14 mL |
| 0.5 mM | 3.3 mL | 16.51 mL | 33.03 mL |
| 1 mM | 1.65 mL | 8.26 mL | 16.51 mL |
| 5 mM | 0.33 mL | 1.65 mL | 3.3 mL |
*The above data is based on the productmolecular weight 605.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21422 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1642303-38-5 |
| Formula | C29H29FN7O5P |
| M. Wt | 605.56 |
| Purity | >98% |
| Synonyms | ITI 214, ITI-214 |
| SMILES | O=C(C1=C(NC2=CC=CC=C2)N(CC3=CC=C(C4=NC(F)=CC=C4)C=C3)N=C1N56)N(C)C5=N[[email protected]@]7([H])[[email protected]]6([H])CCC7.O=P(O)(O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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