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PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.
| In vitro | DMSO | 28 mg/mL (69.05 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.66 mL | 123.31 mL | 246.62 mL |
| 0.5 mM | 4.93 mL | 24.66 mL | 49.32 mL |
| 1 mM | 2.47 mL | 12.33 mL | 24.66 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
*The above data is based on the productmolecular weight 405.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21460 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1301214-47-0 |
| Formula | C23H27N5O2 |
| M. Wt | 405.49 |
| Purity | >98% |
| Synonyms | PF05175157, PF 05175157 |
| SMILES | O=C1CC2(CCN(C(C3=CC=C4C(NC(C)=N4)=C3)=O)CC2)CC5=C1N(C(C)C)N=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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