Biological Activity
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.66 mL | 123.31 mL | 246.62 mL |
0.5 mM | 4.93 mL | 24.66 mL | 49.32 mL |
1 mM | 2.47 mL | 12.33 mL | 24.66 mL |
5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
*The above data is based on the productmolecular weight 405.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A21460 |
---|---|
Actions | Inhibitor |
M. Wt | 405.49 |
Formula | C23H27N5O2 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1301214-47-0 |
Synonyms | PF05175157, PF 05175157 |
SMILES | O=C1CC2(CCN(C(C3=CC=C4C(NC(C)=N4)=C3)=O)CC2)CC5=C1N(C(C)C)N=C5 |
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