TrxR2-IN-1 is a selective inhibitor of thioredoxin reductase 2 (TrxR2) with an IC50 value of 0.83 μM. This compound accumulates in mitochondria, disrupts mitochondrial function and membrane potential, and enhances reactive oxygen species (ROS) production. It activates ASK1-mediated caspase-dependent apoptosis, induces G2/M cell cycle arrest, and reduces cancer cell migration. TrxR2-IN-1 is valuable for investigating hepatocellular carcinoma and related apoptotic pathways in cancer research.
TrxR2-IN-1 is a selective inhibitor of thioredoxin reductase 2 (TrxR2) with an IC50 value of 0.83 μM. This compound accumulates in mitochondria, disrupts mitochondrial function and membrane potential, and enhances reactive oxygen species (ROS) production. It activates ASK1-mediated caspase-dependent apoptosis, induces G2/M cell cycle arrest, and reduces cancer cell migration. TrxR2-IN-1 is valuable for investigating hepatocellular carcinoma and related apoptotic pathways in cancer research.
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