Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Diacylglycerol acyltransferase (DGAT) inhibitors block the final step of triglyceride synthesis. DGAT enzymes transfer a fatty acyl group from acyl-coenzyme A (acyl-CoA) onto diacylglycerol. DGAT1 was identified in 1998 through its sequence similarity to cholesterol acyltransferases. DGAT2, cloned in 2001, shares no sequence similarity with DGAT1 and belongs to a separate gene family. Both enzymes are studied in models of dietary fat absorption, hepatic lipid storage and obesity. A 922500, PF-04620110, AZD7687 and pradigastat are DGAT1 inhibitors, whereas PF-06424439 inhibits DGAT2. Comparing the two classes helps separate the roles of the isoforms in intestine, liver and adipose tissue.
