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GLUT inhibitors and modulators act on glucose transporters, the membrane carriers that move glucose into cells. The glucose transporter (GLUT) proteins belong to the solute carrier family 2 (SLC2) and mediate facilitated diffusion of hexoses. GLUT1 was the first member to be sequenced, in 1985, and its crystal structure was reported in 2014. Because many tumor cells rely on increased glucose uptake, GLUT1 is a frequent subject of cancer metabolism research. BAY-876 was described as a highly selective GLUT1 inhibitor, and WZB117 and STF-31 also target GLUT1. Glutor acts on several isoforms, while D927 promotes GLUT4 translocation for studies of insulin-regulated glucose uptake.
