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Hydroxylase inhibitors block enzymes that add hydroxyl groups to amino acids, amines, steroids or proteins. The section is a mixed set that covers several unrelated enzymes. Tryptophan hydroxylase (TPH) starts serotonin synthesis, with TPH1 in the gut and TPH2 in the brain; LP-533401 and telotristat etiprate inhibit it. Dopamine beta-hydroxylase (DBH) converts dopamine to norepinephrine and is blocked by nepicastat HCl. Hypoxia-inducible factor (HIF) prolyl hydroxylases are oxygen-dependent dioxygenases that mark HIF for degradation; DMOG inhibits this group. Ro 61-8048 targets kynurenine 3-monooxygenase (KMO), and metyrapone inhibits steroid 11-beta-hydroxylase in cortisol synthesis.
