Fig. 1 · Structure
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Cenisertib benzoate
Multi-Kinase Inhibitor
Cenisertib (AS-703569) benzoate is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib benzoate induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib benzoate inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1145859-64-8 |
| Applications | Multi-Kinase Inhibitor |
| Formula | C31H36FN7O3 |
| Molecular Weight | 573.66 |
| Synonyms | AS-703569 benzoate; R-763 benzoate |
| SMILES | OC(C1=CC=CC=C1)=O.NC([C@H]2[C@@](C=C3)([H])C[C@@]3([H])[C@H]2NC4=NC(NC5=CC(C)=C(N6CCN(CC6)C)C=C5)=NC=C4F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.