Fig. 1 · Structure
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Ceranib-2
Ceramidase Inhibitor
Ceranib-2 is a potent ceramidase inhibitor that demonstrates significant inhibition of cellular ceramidase activity, with an IC50 of 28 μM in SKOV3 cells. By inducing the accumulation of various ceramide species and reducing levels of sphingosine and sphingosine-1-phosphate (S1P), Ceranib-2 promotes apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and therapeutic strategies targeting sphingolipid metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1402830-75-4 |
| Applications | Ceramidase Inhibitor |
| Formula | C25H19NO3 |
| Molecular Weight | 381.42 |
| SMILES | O=C1NC(C=CC=C2)=C2C(C3=CC=CC=C3)=C1C(/C=C/C4=CC=C(C=C4)OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.