Fig. 1 · Structure
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Cereblon inhibitor 2
Cereblon Inhibitor
Cereblon inhibitor 2 is an effective inhibitor of the Cereblon protein, primarily targeting its role in regulating substrate degradation through the CRL4 E3 ubiquitin ligase complex. This compound exhibits significant biological activity in inhibiting cancer cell proliferation and enhancing apoptosis, making it a valuable tool in solid tumor research, particularly in breast cancer studies. Its application may facilitate advancements in understanding the molecular mechanisms underlying tumor biology and therapeutic resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2639380-62-2 |
| Applications | Cereblon Inhibitor |
| Formula | C22H21ClN4O4 |
| Molecular Weight | 440.88 |
| SMILES | O=C(NCC1=CC=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=C1)NC4=CC=C(C)C(Cl)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.