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Cevostamab

Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized IgG1-based bispecific antibody (BsAb) designed to target the membrane-proximal extracellular domain of FcRH5 on multiple myeloma (MM) cells, as well as CD3 on T cells. This dual targeting promotes efficient synapse formation between T cells and MM tumor cells, enhancing the cytotoxic activity of T cells against the tumor cells. Cevostamab's unique mechanism of action makes it a valuable tool for research in immuno-oncology and the therapeutic targeting of multiple myeloma.

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Biological Activity

Target & Activity

FcRH5; CD3

Product Details

Manufacturer Adooq Bioscience
CAS Number 2249888-53-5
Molecular Weight 146190
Synonyms BFCR 4350A; RG 6160; RO 7187797

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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