CFTR Corrector 12 (compound 17C) is a bithiazole derivative that acts as a CFTR corrector by promoting the proper folding of defective CFTR mutants. This compound enhances chloride transport across the plasma membrane, making it beneficial for studies involving cystic fibrosis and related disorders. Additionally, CFTR Corrector 12 has been shown to recover α-sarcoglycan (α-SG) levels in mutant cells, indicating its potential in therapeutic approaches targeting CFTR-related pathologies.
CFTR Corrector 12 (compound 17C) is a bithiazole derivative that acts as a CFTR corrector by promoting the proper folding of defective CFTR mutants. This compound enhances chloride transport across the plasma membrane, making it beneficial for studies involving cystic fibrosis and related disorders. Additionally, CFTR Corrector 12 has been shown to recover α-sarcoglycan (α-SG) levels in mutant cells, indicating its potential in therapeutic approaches targeting CFTR-related pathologies.
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