Fig. 1 · Structure
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CGP 20712 dihydrochloride
β 1-adrenoceptor Antagonist
CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist, exhibiting an IC50 value of 0.7 nM. This compound demonstrates approximately 10,000-fold selectivity for β1-adrenoceptors compared to β2-adrenoceptors. It is commonly utilized in cardiovascular research and studies investigating the modulation of heart rate and contractility.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1216905-73-5 |
| Applications | β 1-adrenoceptor Antagonist |
| Formula | C23H27Cl2F3N4O5 |
| Molecular Weight | 567.39 |
| SMILES | O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.