Fig. 1 · Structure
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CGP-53353
PKC Inhibitor
CGP-53353 is a potent protein kinase C (PKC) inhibitor that exhibits IC50 values of 0.41 μM for PKCβII and 3.8 μM for PKCβI. This compound effectively inhibits glucose-induced cell proliferation and DNA synthesis in aortic smooth muscle cells (AoSMC) and A10 cells. CGP-53353 serves as a valuable tool for investigating the mechanisms underlying atherosclerosis in diabetic populations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 145915-60-2 |
| Applications | PKC Inhibitor |
| Formula | C20H13F2N3O2 |
| Molecular Weight | 365.33 |
| Synonyms | DAPH-7 |
| SMILES | O=C1NC(C2=C1C=C(NC3=CC=C(F)C=C3)C(NC4=CC=C(F)C=C4)=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.