Fig. 1 · Structure
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CGP-82996
CDK4/6 Inhibitor
CGP-82996 is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It demonstrates IC50 values of 1.5 μM, 5.6 μM, and 25 μM against CDK4/cyclin D1, CDK6/cyclin D1, and Cdk5/p35, respectively. This compound effectively induces apoptosis in U2OS cancer cells, making it a valuable tool in cancer research to study the modulation of cell cycle progression and cancer cell viability.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 359886-84-3 |
| Applications | CDK4/6 Inhibitor |
| Formula | C27H32N6O |
| Molecular Weight | 456.58 |
| Synonyms | CINK4 |
| SMILES | O[C@H]1CC[C@H](NC2=NC(NC3=CC4=C(N(CC5=CC=CC=C5)C=C4)C=C3)=NC(NCC)=C2)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.