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CHD-1

Hypoxia-activated Antitumor Prodrug

CHD-1 is a hypoxia-activated antitumor prodrug that selectively disrupts mitochondrial morphology and membrane potential in hypoxic tumor cells. This compound induces excessive mitophagy and promotes apoptosis, leading to effective inhibition of hypoxic tumor cell growth in vitro. Additionally, CHD-1 demonstrates significant antitumor activity against HeLa xenografts in vivo, making it a valuable tool for cancer research focused on hypoxia-targeted therapies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3041166-70-2
Applications	Hypoxia-activated Antitumor Prodrug
Formula	C₁₆H₁₂FNO₄
Molecular Weight	301.27
SMILES	FC1=CC(C(/C=C/C2=CC=CC([N+]([O-])=O)=C2)=O)=CC=C1OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.