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CHF-6333 xinafoate

NE Inhibitor

CHF-6333 xinafoate is a potent inhibitor of neutrophil elastase (NE), demonstrating an IC50 of 0.21 nM and a KD of 0.16 nM. This compound maintains its inhibitory efficacy in both human and rat proteases, with IC50 values of 0.22 nM and 3.63 nM, respectively. Additionally, CHF-6333 xinafoate shows significant inhibitory activity against Proteinase 3, with an IC50 of 22 nM. This reagent is particularly applicable in research focusing on bronchiectasis, providing valuable insights into related pathophysiological mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3071964-44-5
Applications	NE Inhibitor
Formula	C₃₈H₃₅F₃N₆O₆
Molecular Weight	728.72
SMILES	FC(F)(C1=CC=CC(N2C(C)=C([C@H](N3C2=NNC3=O)C4=C(C=C(C=C4)C#N)CC[N+](C)(C)C)C(OC)=O)=C1)F.OC5=C(C=CC6=C5C=CC=C6)C([O-])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.