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Chlorasquin

Thymidylate Synthetase Inhibitor, Folate Antagonist

Chlorasquin is a potent inhibitor of thymidylate synthetase, exhibiting a Ki value of approximately 4.9 μM. As a folate antagonist, it demonstrates a stronger binding affinity to dihydrofolate reductase at alkaline pH compared to Methotrexate, suggesting its potential utility in the therapeutic exploration of antipsoriatic agents. Chlorasquin can be leveraged in research applications focused on cancer biology and antifolate studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	18921-73-8
Applications	Thymidylate Synthetase Inhibitor, Folate Antagonist
Formula	C₂₀H₁₉ClN₆O₅
Molecular Weight	458.86
SMILES	O=C(C[C@H](NC(C1=CC=C(C=C1)NCC2=C(C3=C(N=C(N=C3C=C2)N)N)Cl)=O)C(O)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Chlorasquin

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Chlorasquin 25 mg