Fig. 1 · Structure
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Chlormethiazole hydrochloride
Anticonvulsant
Chlormethiazole hydrochloride is a potent GABAA receptor agonist, demonstrating significant anticonvulsant activity. This compound effectively inhibits cytochrome P450 isoforms CYP2A6 and CYP2E1 in human liver microsomes, which may impact its pharmacokinetics. Chlormethiazole hydrochloride is primarily utilized in research aimed at exploring treatments for convulsive status epilepticus and other seizure-related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 6001-74-7 |
| Applications | Anticonvulsant |
| Formula | C6H9Cl2NS |
| Molecular Weight | 198.11 |
| Synonyms | Clomethiazole hydrochloride |
| SMILES | CC1=C(CCCl)SC=N1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.