Fig. 1 · Structure
Documents & Downloads
Chloromethylketone methotrexate
Drug Derivative
Chloromethylketone methotrexate is a derivative of methotrexate that primarily targets dihydrofolate reductase. This compound exhibits potent inhibitor properties and is utilized in various biological research applications, particularly in studies related to cancer therapy and folate metabolism. Its role in modulating cellular pathways makes it a valuable tool for understanding the mechanisms underlying drug resistance and therapeutic efficacy in oncological contexts.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 83160-47-8 |
| Applications | Drug Derivative |
| Formula | C21H23ClN8O4 |
| Molecular Weight | 486.91 |
| SMILES | NC1=NC(N)=NC2=NC=C(CN(C3=CC=C(C(N[C@H](C(O)=O)CCC(CCl)=O)=O)C=C3)C)N=C12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.