Fig. 1 · Structure
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Chlorothymol
LGC-37 Positive Modulator
Chlorothymol is a potent positive modulator of the GABAA receptor subunit LGC-37, exhibiting anticonvulsant and antibacterial activities. It effectively inhibits Pentylenetetrazol-induced c-fos expression and demonstrates growth-inhibitory effects on Methicillin-resistant Staphylococcus aureus (MRSA) strains with a minimum inhibitory concentration (MIC) of 32 μg/mL. Additionally, Chlorothymol provides protective effects against epileptic seizures in various mouse models, making it a valuable compound for researching neurological and infectious diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 89-68-9 |
| Applications | LGC-37 Positive Modulator |
| Formula | C10H13ClO |
| Molecular Weight | 184.67 |
| Synonyms | Chlorthymol; 6-Chlorothymol |
| SMILES | CC(C1=C(O)C=C(C)C(Cl)=C1)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.