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Chloroxoquinoline

Anticancer Agent

Chloroxoquinoline is an anticancer agent that primarily targets DNA within cancer cells, leading to DNA strand breaks and subsequent cell death. It inhibits cell invasion by downregulating the Rho/Rho kinase signaling pathway, thereby exhibiting broad-spectrum anticancer activity against various malignancies, including non-small-cell lung carcinoma (NSCLC), breast cancer, and gastric cancer. Additionally, Chloroxoquinoline has been shown to enhance the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models. However, prolonged exposure in rat models may reduce its efficacy due to auto-induction effects on CYP1A and CYP3A enzymes.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	23833-97-8
Applications	Anticancer Agent
Formula	C₉H₆ClNO
Molecular Weight	179.60
SMILES	O=C1C=CNC2=C1C=CC(Cl)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.