Fig. 1 · Structure
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CHMFL-PI4K-127
PfPI4K Inhibitor
CHMFL-PI4K-127 is a selective inhibitor of the Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4K), exhibiting a potent IC50 of 0.9 nM. This compound demonstrates significant antimalarial activity, with an EC50 of 25.1 nM against the 3D7 strain of Plasmodium falciparum. CHMFL-PI4K-127 is valuable for research in malaria treatment and the exploration of lipid signaling pathways in protozoan parasites.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2377604-81-2 |
| Applications | PfPI4K Inhibitor |
| Formula | C18H15ClN4O3S |
| Molecular Weight | 402.85 |
| SMILES | O=C(C1=CN=CC(C2=CC(NS(=O)(C3=CC=CC=C3)=O)=C(Cl)N=C2)=C1)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.