Fig. 1 · Structure
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Cholesterol 24-hydroxylase-IN-1
CH24H Inhibitor
Cholesterol 24-hydroxylase-IN-1 is a highly selective inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) with an IC50 value of 8.5 nM, demonstrating potent activity. This compound is orally bioactive and capable of crossing the blood-brain barrier, making it a valuable tool for research into cholesterol metabolism and neurodegenerative diseases. Its specificity and ability to penetrate the central nervous system facilitate studies on the role of CH24H in neurological health and disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1613480-70-8 |
| Applications | CH24H Inhibitor |
| Formula | C17H23N5O |
| Molecular Weight | 313.40 |
| SMILES | O=C(C1CCN(C2=C(N3N=CC(C)=C3)C=CN=C2)CC1)N(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.