Fig. 1 · Structure
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Cholesterol 24-hydroxylase-IN-3
CH24H Inhibitor
Cholesterol 24-hydroxylase-IN-3 is a selective inhibitor of cholesterol 24-hydroxylase (CH24H) with an IC50 of 23 nM, designed to penetrate the blood-brain barrier. This compound utilizes the nitrogen atom from its 1,3-oxazole structure to competitively inhibit CH24H activity, while its cyclopropyl group occupies the enzyme's hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 is suitable for research applications focusing on epilepsy and various neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1630746-27-8 |
| Applications | CH24H Inhibitor |
| Formula | C13H10F3N3O2 |
| Molecular Weight | 297.23 |
| SMILES | O=C(C1CC1)NC2=CC(C(F)(F)F)=CC(C3=CN=CO3)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.