Fig. 1 · Structure
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CHR-6494 TFA
Haspin Inhibitor
CHR-6494 TFA is a highly potent inhibitor of haspin, with an IC50 value of 2 nM. By inhibiting haspin, CHR-6494 TFA effectively prevents histone H3T3 phosphorylation, leading to the induction of apoptosis in various cancer cell types, including melanoma and breast cancer. This reagent is valuable for cancer research applications focused on exploring haspin's role in tumorigenesis and the mechanisms of cancer cell survival.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1458630-17-5 |
| Applications | Haspin Inhibitor |
| Formula | C18H17F3N6O2 |
| Molecular Weight | 406.36 |
| SMILES | CCCNC1=NN2C(C3=CC4=C(C=C3)NN=C4)=CN=C2C=C1.OC(C(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.