Fig. 1 · Structure
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Chrysosplenetin
Anti-cancer/Anti-malaria/Anti-osteoporosis Agent
Chrysosplenetin is an orally active polymethoxyflavone that targets multiple pathways to exert its biological effects. It inhibits topoisomerase, leading to DNA protection and apoptosis induction, thereby demonstrating significant anticancer activity. In the context of malaria, Chrysosplenetin acts as a sensitizer, reversing Artemisinin resistance through P-glycoprotein inhibition and enhancing Artemisinin efficacy. Additionally, it promotes bone formation and exhibits anti-osteoporotic effects by activating the Wnt/β-catenin signaling pathway, making it a valuable compound for cancer, malaria, and osteoporosis research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 603-56-5 |
| Applications | Anti-cancer/Anti-malaria/Anti-osteoporosis Agent |
| Formula | C19H18O8 |
| Molecular Weight | 374.34 |
| SMILES | O=C1C(OC)=C(C2=CC=C(O)C(OC)=C2)OC3=CC(OC)=C(OC)C(O)=C13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.