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CI-996

AT1 Receptor Antagonist

CI-996 is a potent and selective orally active antagonist of the angiotensin II (Ang II) type 1 (AT1) receptor. It exhibits high affinity for the AT1 receptor, effectively displacing specifically bound [125I]Ang II in rat liver membranes with an IC50 of 0.8 nM. This compound demonstrates significant blood pressure-lowering activity, making it a valuable tool for research into cardiovascular diseases and hypertension therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	150438-02-1
Applications	AT1 Receptor Antagonist
Formula	C₂₇H₂₂F₃N₇O₃
Molecular Weight	549.50
SMILES	O=C(C1=C(N2C(C(C(F)(F)F)=O)=CC=C2)N=C(CCC)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.