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Cibenzoline succinate

KATP Inhibitor

Cibenzoline succinate is an inhibitor of ATP-sensitive potassium (KATP) channels, specifically targeting the Kir6.2 subunit with an IC50 of 22.2 µM. This compound plays a significant role in regulating insulin secretion and has demonstrated antiarrhythmic and antidiabetic activities. Its application in research includes the exploration of mechanisms underlying diabetes and cardiac arrhythmias, making it a valuable tool for scientific investigations in these fields.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	100678-32-8
Applications	KATP Inhibitor
Formula	C₂₂H₂₄N₂O₄
Molecular Weight	380.44
Synonyms	Cifenline succinate; Ro 22-7796 succinate
SMILES	O=C(O)CCC(O)=O.C1(C2C(C3=CC=CC=C3)(C4=CC=CC=C4)C2)=NCCN1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.