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CID-078

Cyclin A/Cyclin B Inhibitor

CID-078 is a macrocyclic inhibitor targeting cyclin A and cyclin B, effectively disrupting their interactions with cyclin-dependent kinases (CDKs). This compound induces DNA damage and promotes G2/M cell cycle arrest, leading to apoptosis and mitotic catastrophe while activating the spindle assembly checkpoint. CID-078 is pertinent in research applications involving E2F-driven cancer cells and is particularly relevant for studying small cell lung cancer, non-small cell lung cancer, triple-negative breast cancer, advanced solid tumors, luminal HR+/HER2- breast cancer, RB1-altered solid tumors, and neuroblastoma.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3064485-16-8
Applications	Cyclin A/Cyclin B Inhibitor
Formula	C₄₇H₆₃ClF₆N₈O₆
Molecular Weight	985.50
SMILES	ClC1=CC=C(C2=CN(C)N=C2)C(C[C@H](N(C([C@H](CC(C)C)NC3=O)=O)C)C(N(CCCCCCC[C@@H]3N(C([C@H](C4CC4)NC([C@@H]5C[C@@H](F)CN5C(C6(C(F)(F)F)CC(F)(F)C6)=O)=O)=O)C)C)=O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.