Cilastatin-15N,d3 is a stable isotope-labeled derivative of Cilastatin, specifically incorporating 15N and deuterium. As a reversible, competitive inhibitor of renal dehydropeptidase I, it demonstrates an IC50 of 0.1 μM. Additionally, Cilastatin has been shown to inhibit the bacterial metallob-lactamase enzyme CphA, with an IC50 of 178 μM. This reagent serves as an important tool in antibacterial research and studies involving enzyme inhibition mechanisms.
Cilastatin-15N,d3 is a stable isotope-labeled derivative of Cilastatin, specifically incorporating 15N and deuterium. As a reversible, competitive inhibitor of renal dehydropeptidase I, it demonstrates an IC50 of 0.1 μM. Additionally, Cilastatin has been shown to inhibit the bacterial metallob-lactamase enzyme CphA, with an IC50 of 178 μM. This reagent serves as an important tool in antibacterial research and studies involving enzyme inhibition mechanisms.
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