Fig. 1 · Structure
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Cilazaprilat
Angiotensin-converting Enzyme (ACE)
Cilazaprilat is a potent angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 0.7 nM for the rat enzyme. It serves as the active metabolite of Cilazapril and exhibits cardioprotective effects by reducing creatine kinase release in primary neonatal rat cardiac myocytes during ischemia-reperfusion injury at a concentration of 10 μM. Furthermore, cilazaprilat has been shown to enhance coronary blood flow and fractional shortening in canine models experiencing myocardial ischemia due to coronary hypoperfusion. This compound is valuable for research applications related to cardiovascular diseases and ACE inhibition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 90139-06-3 |
| Applications | Angiotensin-converting Enzyme (ACE) |
| Formula | C20H27N3O5 |
| Molecular Weight | 389.45 |
| Synonyms | Ro 31-3113 |
| SMILES | O=C([C@@H]1CCCN2N1C([C@@H](N[C@H](C(O)=O)CCC3=CC=CC=C3)CCC2)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.