Cilengitide trifluoroacetate

Catalog No.: A12371

Integrin inhibitor

Cilengitide trifluoroacetate

Cilengitide trifluoroacetate Chemical Structure

CAS NO. 199807-35-7

Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$200.00
25 mg
$350.00
50 mg
$600.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yi Han Tan, .et al. Complement-activated vitronectin enhances the invasion of nonphagocytic cells by bacterial pathogens Burkholderia and Klebsiella, Cell Microbiol, 2017, Aug;19(8) PMID: 28186697

Biological Activity

Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
Targets
αvβ3 receptor (Cell-free assay) αvβ5 receptor (Cell-free assay)
4.1 nM79 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.23 mL 71.15 mL 142.31 mL
0.5 mM 2.85 mL 14.23 mL 28.46 mL
1 mM 1.42 mL 7.12 mL 14.23 mL
5 mM 0.28 mL 1.42 mL 2.85 mL

*The above data is based on the productmolecular weight 702.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12371
Actions Inhibitor
M. Wt 702.7
Formula C29H41N8O9F3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 199807-35-7
Synonyms EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497
SMILES CC(C)[[email protected]]1C(=O)N[[email protected]](C(=O)NCC(=O)N[[email protected]](C(=O)N[[email protected]@H](C(=O)N1C)Cc2ccccc2)CC(=O)O)CCCNC(=N)N.C(=O)(C(F)(F)F)O

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