Fig. 1 · Structure
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Citraconic anhydride
Antigen Retrieval Solution
Citraconic anhydride is an innovative antigen retrieval solution that primarily targets protein amino groups. By reversibly modifying these groups, it stabilizes specific enzymes and enhances their catalytic activities. Citraconic anhydride reacts with free amino groups on proteins, particularly lysine residues, converting positively charged NH3+ to carboxyl groups, effectively disrupting methylene bridge crosslinks formed by formaldehyde during antigen retrieval. It also functionalizes isostatic polypropylene and demonstrates a precise response to pH changes for reversible modification. Caution is advised as Citraconic anhydride may irritate skin and eyes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 616-02-4 |
| Applications | Antigen Retrieval Solution |
| Formula | C5H4O3 |
| Molecular Weight | 112.08 |
| Synonyms | Methylmaleic anhydride |
| SMILES | O=C1OC(C(C)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.