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Cixutumumab
Cixutumumab (IMC-A12) is a human monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF-1R) with high affinity. It effectively inhibits ligand-dependent activation of the receptor and subsequent downstream signaling pathways. Additionally, Cixutumumab facilitates the internalization and degradation of IGF-1R, contributing to its inhibitory effects. This antibody demonstrates broad-spectrum antitumor activity, making it suitable for research in various cancer types including lung cancer, leukemia, non-small cell lung cancer, and prostate cancer. Cixutumumab is an essential tool for studies exploring the role of the IGF-1R pathway in cancer pathogenesis and therapy.
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Biological Activity
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 947687-12-9 |
| Molecular Weight | 150000 |
| Synonyms | IMC-A12; NSC742460 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.