Fig. 1 · Structure
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CK2-IN-9
CK2 kinase Inhibitor
CK2-IN-9 is a highly selective inhibitor of CK2 kinase, exhibiting an IC50 of 3 nM. This compound effectively diminishes Wnt reporter activity with an IC50 of 75 nM, making it a valuable tool for studying CK2-related signaling pathways. Additionally, CK2-IN-9 demonstrates low systemic exposure and high clearance in rat models, with an AUC of 0.36 μM/h and a clearance rate of 65 mL/min/kg, facilitating its use in pharmacokinetic studies related to CK2 inhibition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1461658-58-1 |
| Applications | CK2 kinase Inhibitor |
| Formula | C23H29N9O |
| Molecular Weight | 447.54 |
| SMILES | O=C(C)NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1N(CCN(C)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.