Fig. 1 · Structure
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CK37
Choline Kinase-α Inhibitor
CK37 is a competitive inhibitor of choline kinase-α, targeting the enzyme's activity in human cells. It effectively suppresses MAPK and PI3K/AKT signaling pathways and disrupts actin cytoskeletal organization. CK37 also diminishes the activating phosphorylations of ERK. This compound demonstrates significant anticancer activity across various cancer types, including cervical cancer, melanoma, Lewis lung carcinoma, lung adenocarcinoma, breast cancer, and leukemia, making it a valuable tool for cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1001478-90-5 |
| Applications | Choline Kinase-α Inhibitor |
| Formula | C20H22N4OS |
| Molecular Weight | 366.48 |
| SMILES | O=C(NC1=CC(C)=CC(C)=C1)CSC2=NN=C(C3=CC=C(CC)C=C3)N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.