Fig. 1 · Structure
Documents & Downloads
CKBA
ACC1 Inhibitor
CKBA is an acetyl-CoA carboxylase 1 (ACC1) inhibitor, exhibiting an IC50 of 5.02 μM. This compound effectively inhibits the differentiation of Th17 cells, with IC50 values of 3.28 μM in mouse cells and 3.61 μM in human cells. In preclinical models, CKBA ointment significantly reduces psoriasis-like inflammation in mice, making it a valuable tool for investigating psoriasis and related inflammatory disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1786406-66-3 |
| Applications | ACC1 Inhibitor |
| Formula | C37H56O5 |
| Molecular Weight | 580.84 |
| SMILES | O=C(O[C@H]1[C@@](C(O)=O)(C)[C@@](CC[C@]([C@@](CC[C@]2(C)[C@@]3([H])[C@@H](C)[C@H](C)CC2)(C)C3=C4)(C)[C@]5([H])C4=O)([H])[C@]5(C)CC1)C6CCCCC6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.