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CKD-731

Fumagillin Analogue

CKD-731 is a Fumagillin analogue that primarily targets MetAP-2, a methionine aminopeptidase involved in protein processing. This compound effectively inhibits the proliferation of calf pulmonary artery endothelial cells, lymphoma EL-4 cells, and murine leukemia P388D1 cells, demonstrating significant anti-angiogenic activity. CKD-731 is suitable for research applications focused on the mechanisms of anti-angiogenesis in cancer models.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	251111-15-6
Applications	Fumagillin Analogue
Formula	C₂₈H₃₈O₈
Molecular Weight	502.60
SMILES	O=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)/C=C/C4=CC(OC)=C(OC)C(OC)=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.