Fig. 1 · Structure
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CL 277082
ACAT Inhibitor
CL 277082 is a potent and selective inhibitor of acyl CoA:cholesterol acyltransferase (ACAT). It exhibits robust inhibitory activity with IC50 values of 0.14 μM in intestinal mucosal microsomes, 0.74 μM in liver microsomes, and 1.18 μM in rat adrenal microsomes. This compound effectively inhibits the ACAT-mediated cholesterol esterification process, making it a valuable tool for research into cholesterol absorption and metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 96224-26-9 |
| Applications | ACAT Inhibitor |
| Formula | C26H36F2N2O |
| Molecular Weight | 430.57 |
| SMILES | O=C(NC1=CC=C(F)C=C1F)N(CC2=CC=C(CC(C)(C)C)C=C2)CCCCCCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.