Fig. 1 · Structure
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CL 316243 free acid
β3-Adrenoceptor Agonist
CL 316243 free acid is a selective β3-adrenoceptor agonist, exhibiting an EC50 of 3 nM while demonstrating minimal activity at β1 and β2 receptors. This compound effectively stimulates lipolysis in adipocytes and enhances thermogenesis in brown adipose tissue, thereby elevating metabolic rate. Its potential applications include the study and treatment of obesity, diabetes, and urge urinary incontinence.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 183720-02-7 |
| Applications | β3-Adrenoceptor Agonist |
| Formula | C20H20ClNO7 |
| Molecular Weight | 421.83 |
| SMILES | O=C(C1(C(O)=O)OC2=CC=C(C[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)C)C=C2O1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.