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Cladophorol A

cGAS Inhibitor

Cladophorol A is a selective cGAS inhibitor that modulates the cGAS-STING pathway by binding to its conserved adenosine nucleobase binding site, effectively blocking cGAS activity. Demonstrating an IC50 of 370 nM at non-cytotoxic concentrations, Cladophorol A provides a valuable tool for research focused on inflammatory diseases associated with cGAS-STING overactivation. Its application in studying these pathways can enhance understanding and development of therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	146776-30-9
Applications	cGAS Inhibitor
Formula	C₁₃H₈O₆
Molecular Weight	260.20
SMILES	O=C1OC2=CC(O)=C(C=C2C3=C1C=C(O)C(O)=C3)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.