Fig. 1 · Structure
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Clathrin-IN-4
Endocytosis/dynamin I GTPase Inhibitor
Clathrin-IN-4 is a potent inhibitor of clathrin-mediated endocytosis, primarily targeting dynamin I GTPase activity with an IC50 of 9.1 μM. This compound demonstrates robust inhibition of endocytic processes, making it a valuable tool for researchers investigating vesicle trafficking and cellular uptake mechanisms. Its effectiveness in blocking dynamin I activity at an IC50 of 2.1 μM highlights its utility in studying the dynamics of cellular membrane remodeling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 762242-59-1 |
| Applications | Endocytosis/dynamin I GTPase Inhibitor |
| Formula | C17H18Br2N2O |
| Molecular Weight | 426.15 |
| SMILES | CN(C[C@H](CN1C2=CC=C(C=C2C3=CC(Br)=CC=C31)Br)O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.