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Clathrin-IN-5

clathrin N-terminal domain-amphiphysin protein-protein interaction Inhibitor

Clathrin-IN-5 is a potent inhibitor of the clathrin N-terminal domain-amphiphysin protein-protein interaction, with an IC50 of 2.77 μM. This compound effectively disrupts clathrin-mediated endocytosis, achieving an IC50 of 4.6 μM. Additionally, Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM. It is valuable for studying the mechanisms of endocytosis and associated cellular processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	339025-18-2
Applications	clathrin N-terminal domain-amphiphysin protein-protein interaction Inhibitor
Formula	C₁₆H₁₀ClNO₃
Molecular Weight	299.71
SMILES	OC1=CC(NC(C(C2=C3C=CC=C2)=O)=C(Cl)C3=O)=CC=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.