Fig. 1 · Structure
Documents & Downloads
Clitocine
Nonsense Mutations Suppressor
Clitocine is an adenosine nucleoside analog derived from mushrooms that functions as a potent suppressor of nonsense mutations. It is capable of inducing the expression of p53 protein in cells with p53 nonsense mutations, thereby contributing to apoptosis in multidrug-resistant human cancer cells through the targeting of Mcl-1. Clitocine serves as a valuable tool for research applications focusing on cancer biology and the mechanisms of genetic diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 105798-74-1 |
| Applications | Nonsense Mutations Suppressor |
| Formula | C9H13N5O6 |
| Molecular Weight | 287.23 |
| SMILES | OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=C([N+]([O-])=O)C(N)=NC=N2)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.