Fig. 1 · Structure
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CLK-IN-T3
Selective CLK Inhibitor
CLK-IN-T3 is a highly potent and selective inhibitor of CDC-like kinases (CLKs), exhibiting IC50 values of 0.67 nM for CLK1, 15 nM for CLK2, and 110 nM for CLK3. This compound demonstrates significant anti-cancer activity, making it a valuable tool for research applications focused on cancer biology and the modulation of spliceosome activity. Its specificity for CLK isoforms allows for targeted studies in kinase signaling pathways and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2109805-56-1 |
| Applications | Selective CLK Inhibitor |
| Formula | C28H30N6O2 |
| Molecular Weight | 482.58 |
| SMILES | CC(C1=CC=C(C(NC2=CN3C=C(C4=CC=NC=C4)C=CC3=N2)=O)C=C1)(C)C(N5CCN(C)CC5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.