Fig. 1 · Structure
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CLK1-IN-4
CLK1 Inhibitor
CLK1-IN-4 is a selective inhibitor of CDC-like kinase 1 (CLK-1) with an IC50 value of 2.5 μM. This compound modulates alternative splicing by inhibiting CLK-1, making it a valuable tool for studies investigating the regulation of gene expression and the functional implications of splicing variation. CLK1-IN-4 is applicable in research related to cancer biology and other diseases where splicing dysregulation plays a significant role.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 332939-32-9 |
| Applications | CLK1 Inhibitor |
| Formula | C18H18N2O2S |
| Molecular Weight | 326.41 |
| SMILES | CCCC(NC(C1=CC=C2C=CC=NC2=C1O)C3=CC=CS3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.