Fig. 1 · Structure
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CLK8
CLOCK Inhibitor
CLK8 is a potent and selective inhibitor of the CLOCK protein, functioning by disrupting the interaction between CLOCK and BMAL1 as well as interfering with the nuclear translocation of CLOCK. This compound is valuable for investigating disorders related to impaired circadian rhythms, providing insights into the biological implications of clock gene dysregulation. Researchers can utilize CLK8 to explore the mechanistic roles of CLOCK in various physiological and pathophysiological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 898920-65-5 |
| Applications | CLOCK Inhibitor |
| Formula | C29H26N2O6 |
| Molecular Weight | 498.53 |
| SMILES | O=C(COC1=C(C(C2=CC=CC=C2)=CC(O3)=O)C3=C(CCC(C)(C)O4)C4=C1)NC5=C(C(N)=O)C=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.