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Clofarabine-5'-triphosphate

Cytotoxin

Clofarabine-5'-triphosphate is the active metabolite of Clofarabine, produced by phosphorylation via deoxycytidine kinase (dCK). This compound exerts cytotoxic effects in cancer cells by inhibiting DNA synthesis and DNA repair mechanisms. It serves as a valuable reagent for research in cancer therapeutics and drug resistance studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	134646-41-6
Applications	Cytotoxin
Formula	C₁₀H₁₄ClFN₅O₁₂P₃
Molecular Weight	543.62
Synonyms	Clofarabine-TP
SMILES	NC1=NC(Cl)=NC2=C1N=CN2[C@H]3[C@@H](F)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.